FISCHBACH Laboratory - Kevin Lüthy

FISCHBACH Laboratory

Kevin Lüthy

PhD Student

Mechanisms of the Differential Transport of IRM Proteins

    Project Description

    As PhD student of the Fischbach laboratory I analyze IRM protein expression in the central brain to understand neuron outgrowth and axonal pathfinding in Drosophila. Using transgenic flies in which targeted overexpression manipulates IRM protein levels I determine their physiological role in the nervous system, especially in the synaptic region. Homologue proteins are expressed in mammals, and it will be interesting to discover conserved functions of the IRM in mammal and fly.


2004 - 2009 Studies of Biology at the Julius-Maximilians-Universität Würzburg
2007 - 2008 Diploma Thesis 'The Role of STIM1- and STIM2-dependent Calcium Influx in Murine T Cell Activation for in vitro Migration and Cytotoxicity'
Current Occupation      Albert-Ludwigs-University, Freiburg, Germany, Ph.D. student with Prof. Karl-Friedrich Fischbach


  1. Picard C, McCarl CA, Papolos A, Khalil S, Lüthy K, Hivroz C, LeDeist F, Rieux-Laucat F, Rechavi G, Rao A, Fischer A, Feske S. 2009. STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N. Engl. J. Med. 360:1971-80.

  2. Ma J, McCarl CA, Khalil S, Lüthy K, Feske S. 2010. T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells. Eur J Immunol. 40:3028-3042.

  3. Helmstädter M, Lüthy K, Gödel M, Simons M, Ashish, Nihalani D., Rensing S.A., Fischbach K.-F., Huber T.B. 2012. Functional Study of Mammalian Neph Proteins in Drosophila melanogaster. PLoS ONE 7(7): e40300. doi:10.1371/journal.pone.0040300

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