irregular chiasm C - roughest (irreC-rst)

an adhesion molecule required for axonal navigation and certain programmed cell deaths

Adult phenotype of UB883. Composite of camera lucida drawings of Golgi impregnated preparations. Fibers exiting the posterior lamina project in an irregular manner via the second optic chiasm into the anterior medulla (arrow). L1-L5, lamina monopolar neurons 1-5. R7, axon of retinula cell 7.

Abstract of Boschert et al. 1990 (adult and pupal irreC phenotypes)
Abstract of Ramos et al. 1993 (cloning of irreC-rst )
Abstract and images of Schneider et al. 1995 IrreC-rst function in the optic lobe
Abstract of Reiter et al., 1996. Role of IrreC-rst in eye development.
other irreC-rst literature

Other Informations

map position: 3C5
IrreC-rst protein: neural recognition molecule of the immunoglobulin superfamily
The chicken axonal surface protein DM-GRASP/BEN/SC1 is most related.
Sequence comparison
Some important irreC-rst alleles:
- UB883 (P-element insertion, hypomorph)
- 1R34 (Xray induced inversion breakpoint, no gene products detectable, but phenotypically somewhat less severe than Df(1)rst-vt )
- Df(1)rst-vt (genomic null)
- rst(CT) (altered protein: partial deletion of the intracellular domain)
genomic map of irreC-rst locus
amino acid sequence of HB3 cDNA
Not all data are linked yet:
mutant phenotypes:
- no embryonic phenotypes yet described
- larval
- pupal optic lobe
- adult optic lobe
protein expression pattern in
- embryo
- larval brain (images of Schneider et al., 1995)
- pupal brain (images of Schneider et al., 1995) & unpublished:
- adult flies is hardly detectable
phenotypes after GAL4/UAS-misexpression
- in the larval and pupal optic lobe
- in the pupal central brain
- in the adult brain
personalized "irre" history